Viral Genome Sequencing and Evolution
Students will study the evolution of viral genomes by determining the DNA sequence of bacteriophage genomes related to T4. Students will make generate DNA templates and perform DNA sequencing reactions on them. Additional regions of the genome will be amplified and sequenced using PCR. Students will use computer programs to assemble sequences and compare them to known genomes in order to identify genes that have been acquired or lost in the viral DNA.